hey what's up guys so for those of you that don't know derek from more plates more dates
just released his testosterone optimization uh product known as sigma that he formulated
alongside andrew huberman however the reason i'm making this video is because they included
a fairly controversial ingredient in their product known as fedoja agustus which i have been fairly
critical of in the past because of its possible toxicity oh my god no way now because of the video
that i did on fedoja agrestis several months ago i've been getting a ton of questions uh to do a
video review on his formulation and the product as well as a ton of questions on whether or not
my opinions on fedoja aggressors have changed since i released my first video so essentially
what i want to do in this video is clarify some of the statements that i made in my previous video
as well as dive a little bit deeper into the toxicity data so that you guys can get a better
idea of whether or not this is something that you would like to take so let's go ahead and dive
right in now for anyone that's not super familiar with the controversy surrounding fedoja aggress
um about a year ago andrew huberman went on to the joe rogan experience and was talking about ways
to optimize testosterone levels and mentioned a couple of supplements that could be used to
increase testosterone namely fedoja agustus and tonkat ali and ever since he went on that podcast
the market for these supplements has absolutely exploded however a few months after uh andrew
went on the joe rhode experience i did a video outlining my concerns about the possible toxicity
of fedoja aggressis and that video has gained a lot of momentum here on youtube as well as
on reddit in some specific forums now to be clear i am a huge fan of both andrew and
derek i think they are some of the brightest minds in kind of the arena of men's health
they don't appear to be dogmatic at all which is something that i highly appreciate and they
both appear to be extremely genuine guys um and so this is by no means a video bashing them or their
opinions to be quite frank i have a very high opinion of both of them if you were a chick who's
the one guy you would sleep with now the criticism that i've gotten most often since i released my
initial video on fedocia aggressus is that the dosages that were used in the rodent trials were
extremely high and therefore don't correlate over into human dosages and though i didn't talk about
this directly in my initial video this is actually not true at all now there are two primary studies
that have been performed in order to assess the toxicity of fedoja aggress and in both of these
studies they used a dosage schedule of 18 50 and 100 milligrams per kilogram of body weight
now what most people end up doing in order to get a human equivalent dose is that they will end up
just taking their body weight in kilograms and multiplying it by these dosages to get a human
equivalent dosage unfortunately this is not how this works it is generally accepted that in order
to properly calculate a human equivalent dosage from a rodent dosage that you first have to divide
the rodent dosage by 6.2 before you calculate the human equivalent dosage now this is for several
reasons however it is namely because rodents have a much lower body surface volume as
well as a much higher metabolism and so because of this you just can't take a rodent dosage and then
immediately calculate the human equivalent dosage and if we're going to take this generally accepted
approach of calculation you actually get a human equivalent dosage roughly equal to 2.9 8.1 and
16.1 milligrams per kilogram of body weight which for a 200 pound male equals roughly 260
725 and 1450 milligrams which is very much in line with the typical recommended dosages now this is
not to say that there isn't still some nuance when it comes to calculating human equivalent dosages
from rodent dosages however there does appear to be some level of toxicity with fedoja aggresses
even at lower dosages now andrew and derek have both been fairly clear and open about the risk
of toxicity and side effects when it comes to using fedoja aggressors however until we have
more data i do believe that these risks should be taken somewhat seriously now another uh common
criticism that i've gotten regarding my initial video on fedoja is that i was extremely dismissive
of fedoja's ability to increase testosterone in rodents but was not dismissive of its toxicity
in rodents and the reasoning here is that hey zach if you're going to brush off the possibility
of fedoja increasing testosterone just because it's only been demonstrated in rodents why aren't
you also just simply brushing off the possibility of side effects simply because they have also
only been demonstrated in rodents and to some degree this is actually a fair criticism however
my reasoning here is that if you're going to be taking unproven and experimental supplements to
increase testosterone you have to take into account the risk to reward ratio and what i
mean by this is if you're going to be taking an unproven supplement ideally you want it to have
an extremely safe safety profile and my reasoning here is what's the point of taking something that
might increase testosterone if the risk of side effects and toxicity are just as likely however i
do think it is important to keep in mind here that this is very very case dependent and dependent on
circumstances for instance if you actually do have low testosterone and clinically low testosterone
the risks of having low testosterone in some individuals might actually be higher
than the risks of toxicity now because of all of this this is one of the reasons
that i um included fedoja aggressive as one of the experimental compounds that could be used
to increase testosterone in my complete guide to supplementation however if you are interested in
checking out and learning more about some of the supplements that i consider to be
complementary and foundational to increasing and optimizing testosterone production
i would definitely recommend checking out the link in the description to gain access to that
complete guide to supplementation now with all of that being said and after having a handful
of conversations with derek about why he included fedoja agrestus in his formulation um i actually
don't believe the risks of side effects and the risk of toxicity to be as great as i once thought
now there are a couple of reasons for this however the first reason is that when i shot my original
video one thing that i did not take into account was the time of exposure now derek has done a
fantastic job of outlining his thought process on that in his own video however just to kind of like
give a synopsis of it here when you are converting rodent dosages to human dosages it is important
and extremely important to keep in mind that a single day in rodents is not equal to a single day
in humans so now all of these studies that were performed on the toxicity of fedoja used a dosing
schedule of roughly 1 to 28 days and what this means is that one day in rodents is roughly equal
to about 30 days of supplementation in humans and 28 days of supplementation in rodents is roughly
equal to about three years in humans now the reason this is so important is that there is
a theoretical safe zone when it comes to fedoja aggressive supplementation meaning that you could
possibly take it for up to 30 days and experience the benefits of taking fedora aggressors without
experiencing some of the signs of toxicity now the second reason that i don't believe the risk
of toxicity with fedoja aggressors to be as high as i once thought is that it is entirely possible
that fedocia aggressors is toxic to rodents but not to humans now i think one of the clearest
examples of this is with something like chocolate that is fairly toxic to dogs but is not toxic to
humans now if i was talking to someone like paul saladino he would probably make a fairly strong
argument as to why he thinks chocolate is toxic to humans however my point still stands um humans
do have the ability to process enzymatically the the compounds that are in chocolate however
dogs just don't have that and so it is entirely possible that this is a similar case with fedosia
in that the rodents just simply don't have the enzymatic processes necessary to properly digest
and break down the compounds that are in fedoja now this is not to say that the risk of side
effects and toxicity with fedoja is zero there is some evidence to suggest that there might be some
kidney and liver enzyme elevation even after a single day in rodent trials which roughly equates
to about 30 days of supplementation in humans so again the risk here isn't zero however it does
still create some room for this theoretical safe zone with fedozia aggressive supplementation
now when it comes to the actual side effects of fedoja one of the only side effects that i have
heard from reports is that there might actually be too much of a stimulation of the lettuce cells to
produce testosterone and this might be where some of the toxicity is coming from when it comes to
specifically the testicular toxicity however if you are taking fedozia and do kind of experience
like achy junk so to speak um i would discontinue a fedoja aggressive use however it just isn't
super clear um just how high this risk is yet so what's the takeaway here well the takeaway
is if you're going to take fedoja aggress i would highly recommend getting some dang blood work done
first now for any of you guys have been following my content for a while you'll know that i'm a huge
fan of at home testing however in this particular instance i do believe that it would be in your
best interest to get something a little bit more comprehensively done now the reason for this is
that when you are taking something like fedoja there are a handful of things that you want to be
keeping an eye on namely gonadotropin levels and specifically lh levels and ensuring they're not
going super super high because when lh levels do go through the roof there is again that risk of
over stimulating the lead cells of the testes to produce testosterone which may lead to some level
of toxicity so you want to be keeping an eye on that as well as your kidney and liver enzymes
now another thing that you want to be testing is obviously your testosterone levels to see if
fadoja is actually something that you actually need because if you don't need an increase in
testosterone you may not need to take something like fedoja now if you guys are interested in
getting a full panel like this done i would highly recommend my friends over at merrick
health they have a fantastic full panel that you guys can access in the description so just go down
there and click on the link and it will take you directly to that page now if you are considering
taking fedoja i would just straight up just go take sigma derek's product he did a fantastic
job of formulating it with some other compounds that i've talked about extensively on my channel
things like ashwagandha and tongkat ali and boron and so he has a fantastic formula that they have
produced over there and so if you're interested in taking something like that again there's going to
be a link in the description where you guys can follow to purchase that but other than that guys
make sure to check out that complete guide to supplementation if supplementation is something
that you are particularly interested in it will be an extremely invaluable resource to you but other
than that leave a comment down below if you have any questions and i will see you guys next time